Adhesion: 
Hot Melt Tape wins when it comes to adhesion strength. It has significantly higher adhesion as compared to acrylic tape on most surfaces including fiberboard.
Value:
Hot Melt Tape has a very strong holding power and is more flexible, therefore performing better under constant stress.
Price:
Both hot melt tape and acrylic tape are comparable in price, offering both economy and premium options.
Temperature:
Both Hot Melt Tape and Acrylic Tape are functional in hot and cold temperatures. However Acrylic Tape holds up better in extremely low temperatures and is ideal for refrigerated or frozen storage units.
Appearance: 
Hot melt tape comes in a variety of colors and can yellow with age. Acrylic tape is less likely to oxidize and doesn’t yellow with age even if its under direct sunlight.
Best Use: 
Hot melt tape is ideal for shipping boxes due to its superior holding box and will ensure that the box stays sealed. For boxes that will be kept in storage for long periods of time, acrylic tape can maintain its seal for more than three years and is more resistant to temperature extremes occurring in non-conditioned storage space.
Application: 
Both hot melt tape and acrylic tape can be hand or machine applied, but typically the hot melt works better on the machine.

Overall, when it comes to deciding between hot melt tape and acrylic tape for sealing a package, hot melt tape gets the job done in most applications. Acrylic is good for long-term storage in extreme temperatures. Hot melt tape provides a stronger bond, adheres more quickly, and takes less time to apply. Its great for bulk packages and for packages that will have to withstand a lot of pressure.